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Benefits of Combining Cannabinoids

Pizza and pepperoni, burger and fries, peanut butter and jelly – these are all good individually, but even better together.  Cannabinoids can behave the same way!  You may already be taking CBD or another cannabinoid like Delta 8.  However, by mixing some cannabinoids, they can produce what’s called the ‘entourage effect’, causing them to be more potent when taken together than when taken individually.

shown burger and fries, pizza and pepperoni, peanut butter and jelly representing the benefits of combining cannabinoids

More and more people are reporting better results by combining non-addicting hemp cannabinoids.  Some people choose the full spectrum route and use a premium quality full spectrum tincture or gummy.  But the future is here with the recent release of many new combinations.  This also introduces the flexibility of creating our own combinations based on specific needs.  In this blog, we’ll discuss a few combinations and their potential benefits when used together.

CBD (Cannabidiol)

So, you thought CBD was the only cannabinoid out there.  You may be surprised to learn that there are over 100 identified cannabinoids.  Yes, CBD has some amazing properties and benefits by itself. There is strong evidence showing CBD can help relieve pain, has anti-inflammation and anti-anxiety properties and may help with many seizures causing epilepsy syndromes like Dravet Syndrome, Lennox-Gastaut Syndrome, and Tuberous sclerosis complex. More research is needed, but it also looks as if there is some hope for those who suffer from Parkinson’s, Multiple Sclerosis (MS), diabetes, and even some types of cancer.  Reports also show promise for help with addiction to opioids, PTSD, Arthritis, and Insomnia. 

CBN (Cannabinol) + CBD

Problems sleeping due to pain? Are you just taking CBD or just CBN?  The combination of the sedative effect of CBN with the added relaxation of CBD may help you rest easier.  CBN helps to regulate pain, inflammation and like CBD, also has sedative effects.  People often report relief of the symptoms of Crohn’s disease when using the combination of CBN and CBD.  It turns out that this is a pretty powerful combination.  Research is still in its early stages but there is promising information that combining CBN and CBD can help to reduce pain and also provide sedative effects.  Those with Fibromyalgia may also get some relief from the chronic pain they suffer. If you are suffering from any of these diseases, talk with your doctor about adding these cannabinoids to your daily routine for a better quality of life!

CBD + THC (Delta-9-tetrahydrocannabinol)

People with Multiple Sclerosis (MS) around the world recently were pleased to learn that MS-related spasticity (abnormal tightness of the muscle from prolonged contraction) can find relief with the combination of THC and CBD.  In a study published by the NIH, the combination of THC and CBD was shown to suppress neuroinflammation.  It is believed that the combination of these two cannabinoids plus terpenes is a powerful mix.  We hope to see more clinical trials for those with MS or other newly discovered cannabinoids that may also bring relief. 

Delta 8 + CBN

The wonders of Delta 8 (delta-8-tetrahydrocannabinol), where to start.  First Delta 8 is an isomer of Delta 9, which is the cannabinoid in weed that gets you high. Both have very similar qualities with the exception that Delta 8 is less psychoactive and gives a much milder high than Delta 9.  If you suffer from nausea like I do, Delta 8 is a godsend as it has been proven to reduce nausea and stimulate appetite. Delta 8 also relieves pain and can prevent vomiting for those coping with cancer treatments.  When Delta 8 is combined with CBN, the CBN helps to reduce the energetic aspects of the Delta 8 to help bring an extremely comfortably body focused feeling, which can be perfect for a peaceful relaxing day or night of relief.

THCV (Tetrahydrocannabivarin) + Delta 8

By itself, THCV can help you feel uplifted, alert, and energized.  Mix in some Delta 8 and you can get an incredible boost.  Perfect for a mid-day pick-me-up without the jitters in other products.  THCV and Delta 8 can clear your mind, make you feel alert, awake and may control your appetite.

Reported in a controlled clinical trial in 2016 by the NIH, “THCV could represent a new therapeutic agent in glycemic control in subjects with type 2 diabetes”. Clinical human trials still need to be done but there is some promising information published in an animal study in regards to Parkinson’s disease.  It shows promise in alleviating symptoms and delaying the neurodegeneration progression of this disease. We hope that more studies are done to confirm this in humans.

Edibles or Tincture?

What should I take, an edible or a tincture?  How quickly would you like to feel the effect of the product you’re using? Premium edibles can be delicious but will always take longer to work than a tincture. Why? Edibles need to be digested then absorbed by the liver and into your blood stream.  Whereas a tincture is taken sublingually (placed under the tongue for recommended time then swallowed).  This pathway is much quicker than edibles because the cannabinoids are absorbed into your bloodstream and relief can be almost immediate. Edibles can take from 30 minutes to up to two hours to feel the full effects. Digestion and absorption take time. So don’t munch down all those gummies you just got so quickly.  


Combining cannabinoids can have increased effects and uses that can help bring a better quality of life to you when you are struggling through an illness. Multiple experimental models of cannabinoids have been shown that in autoimmune disorders such as multiple sclerosis, rheumatoid arthritis, colitis and hepatitis, cannabinoids can help prevent the development of the disease by multiple anti-inflammatory pathways.

The information above is not intended to be a substitution for a physician’s advice.  We always recommend you do your own research and consult your physician.  We believe that if you are struggling with a debilitating disease, you should have all options available to you so that you can live a life and not a disease.

Cannabinoid Combinations for you

koi cbd anytime gummies shown in and out of bag
CBD Gummies
comfortably numb delta 8 thc cbn gummies 16 count shown in bag
CBN + Delta 8 Gummies
koi complete pomegranate full spectrum gummies
CBD + THC Gummies
shown koi thcv + acv gummies and 3chi thcv + delta 8 gummies
THCV + ACV & THCV + Delta 8 Gummies
focus cbd oil 500 mg with terpenes front
CBD Tincture
comfortably numb delta 8 thc & cbn tincture 1200 mg by 3chi
CBN + Delta 8
delta 8 oil tincture 1000 mg blue raspberry by pharma grade
Delta 8 Tincture
nano thcv oil tincture sports 300 mg by cbdism, thcv tincture, thcv drops
THCV Tincture
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